Resodyn Acoustic Mixers

Hyaluronic Acid Crosslinking

Hyaluronic Acid Crosslinking in as Little as 1 Minute with ResonantAcoustic Mixing!

ResonantAcoustic® Mixing (RAM) for Innovation in Cosmetics and Pharmaceuticals.

How can RAM help you?
Successful application of ResonantAcoustic® Mixing (RAM) technology to Hyaluronic Acid (HA) Crosslinking...

...leads to significant technological advantages....

...and at the same time allows crosslinked HA gels.

We strongly believe this RAM technology will find its way for creation of new and highly valuable dermafillers and joint injection products.

Feliyx Polyak, Ph.D. President - Studio Bioscience speaking at International Society for Hyaluronan Sciences ( ISHAS 2023)

 

How can RAM help you?

Patent WO 2023/184029 AI:

METHOD FOR CROSSLINKING HYALURONIC ACID USING RESONANTACOUSTIC® MIXING (RAM)

Patent Excerpts:

https://patents.google.com/patent/WO2023184029A1/en

The crosslinking of hyaluronic acid is central to making it biologically and chemically more stable. Moreover, crosslinking also imparts improved chemical, physical and rheological properties.

Performing the crosslinking at room temperature advantageously provides for preventing potential decomposition of the polymer at more elevated temperatures such as 50°C, especially when the crosslinking is performed over extended periods of time such as one or more hours.

Decomposition may be especially problematic with carbohydrate polymers such as hyaluronic acid.

Moreover, in addition to providing for greater reproducibility, the process for crosslinking a polymer (e.g., a carbohydrate polymer such as hyaluronic acid) using resonant acoustic mixing, advantageously provides for crosslinked materials having improved physical and rheological properties.

In an embodiment of the present disclosure, the polymer is a carbohydrate polymer, non-limiting examples of which include hyaluronic acid. In an embodiment of the present disclosure, the BDDE-crosslinked hyaluronic acids obtained using resonant acoustic mixing have high dynamic viscosities and a relatively high storage modulus G’ and loss modulus G” relative to the commercial dermal fillers RHA®1 , RHA®2, RHA®3 and RHA®4.

Consequently, the use of resonant acoustic mixing for crosslinking a carbohydrate polymer (e.g., hyaluronic acid) advantageously provides for dermal fillers having improved physical and rheological properties.

The rheological properties of BDDE-crosslinked hyaluronic acid obtained in accordance with an embodiment of the present disclosure using resonant acoustic mixing, were compared with BDDE-crosslinked hyaluronic acid obtained using standard chemical crosslinking techniques. BDDE-crosslinked hyaluronic acid is the main ingredient in the most commonly used commercial dermal fillers.

The rheological properties of commercial dermal fillers such as Juvederm Ultra® XC, Juvederm Ultra Plus® XC, Juvederm Voluma® XC, Restylane Fynesse®, Restylane Kysse®, Restylane Volyme®, Restylane Refyne®, Restylane Silk®, Belotero Balance® were measured and compared to BDDE-crosslinked hyaluronic acid obtained using resonant acoustic mixing.

The data illustrated in the patent demonstrate that crosslinked hyaluronic acids obtained by resonant acoustic mixing exhibit unique and advantageous rheological properties.

To that effect, BDDE-crosslinked hyaluronic acids obtained by resonant acoustic mixing exhibit high dynamic viscosities, making the material advantageously useful as a dermal filler. To that effect, the observed high dynamic viscosities provide for easy and smooth injection of the material, even when using high gauge needles.

Moreover, BDDE-crosslinked hyaluronic acids obtained by resonant acoustic mixing exhibit advantageous elasticity relative to the best currently available commercial fillers.

Furthermore, the use of resonant acoustic mixing to effect the crosslinking of hyaluronic acid provides for rapid reaction times, lower reaction temperatures, and substantially does away with isolation and purification procedures, characteristic of standard chemical crosslinking.

However, a purification step and/or sterilization step may be incorporated into the process for preparing crosslinked polymers using resonant acoustic mixing. A further advantage of resonant acoustic mixing is that the rheological properties of the crosslinked material can be easily modified by changing the mixing parameters such as the forcing energy and/or frequency.

 

 

Credit:

Feliyx Polyak, Ph.D. President - Studio Bioscience speaking at International Society for Hyaluronan Sciences ( ISHAS 2023)

#hyaluronicacid #dermafillers #cosmeticsmanufacturer

How can RAM help you?