Resodyn Acoustic Mixers

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ONLY RAM GIVES YOU ACCURACY, REPEATABILITY & PURITY IN CHEMICAL MIXING & DEVELOPMENT

Resonant Acoustic Mixing (RAM) is increasingly used in chemical mixing because it solves many challenges that traditional mixing methods can't handle efficiently or safely. Here's how it's being used successfully in chemical mixing applications worldwide:


🔬 1. Homogeneous Mixing of Multi-Phase Chemicals

RAM can mix liquids, solids, gases, and their combinations uniformly, even when viscosities differ drastically or when materials are immiscible (like oil and water).

Success Example:
Blending liquid-liquid reactants with vastly different viscosities (e.g., glycerin with hexane) without creating emulsions or requiring surfactants.


🧪 2. Mechanochemistry (Solid-State Reactions)

RAM enables chemical reactions between solid reactants—no solvents needed. This is called mechanochemistry, and RAM excels here because it delivers high energy without direct contact.

Success Example:
Synthesizing metal-organic frameworks (MOFs), catalytic powders, or organics without solvents, reducing environmental impact.

Check out RAM and mechanochemistry in the digital exhibit, Mix, Crush, Shear from the Science History Institute's website.


⚗️ 3. In-Situ Reactions in Closed Containers

RAM can perform chemical reactions directly in sealed vessels, maintaining an inert atmosphere (e.g., nitrogen or argon) or applying vacuum or temperature control with jacketed containers.

Success Example:
Reactive blending of hazardous or air-sensitive chemicals without exposure or cleanup.


🧴 4. Coating, Encapsulation & Surface Modification

RAM uniformly coats powders, particles, or granules with chemical layers (e.g., polymers, catalysts, lubricants) without using excess solvents or binders.

Success Example:
Applying anti-caking agents or chemical coatings to explosives or energetic materials (used by DoD and NASA).


⏱️ 5. Ultra-Fast Reaction Times

RAM significantly shortens reaction and mixing times due to high energy transfer—mixing is often 10x to 100x faster than traditional mixers.

Success Example:
Speeding up polymer precursor mixing or batch chemical synthesis where reaction kinetics are limited by diffusion.


💡 Why It Works So Well in Chemical Applications

  • No blades or shafts: Zero shear degradation of sensitive reactants.

  • Non-contact: No contamination and easy cleanup—especially valuable for hazardous or toxic chemicals.

  • Consistent energy distribution: Results in repeatable, scalable reactions.

  • High safety profile: Used in defense, pharma, and aerospace for sensitive or explosive chemistries.


🔧 Typical Chemical Mixing Use Cases

  • Polymer blending and compounding

  • Catalysis and catalyst support coating

  • Solvent-free reactions

  • Nanomaterial dispersion

  • Battery material preparation (e.g., anodes, cathodes)

  • Pharmaceutical synthesis and API mixing

RAM mixers provide 10X to 100X faster mixing and dispersion rates with increased intra-batch uniformity and consistency.

Both heating and cooling systems can be applied for tighter reactive process control and increased consistency of the chemical blending process. 

Rapid emulsification and extended life suspensions provide immense benefits to chemical mixing with RAM.

Applications for RAM products in the Chemical Mixer Industry is uncapped and inclusive of:

  • Catalysts
  • Chlorinated Organics
  • Epoxy Hardeners
  • Floatation Reagents
  • Gas Storage Materials
  • Lubricant Pastes & Oils
  • Mechanochemistry
  • Optical Brighteners
  • PVB Emulsions
  • Specialty Chemicals
  • Technical Polymers
  • Thermal Transfer Materials
  • And Many More
Chemical Mixing and Mechanochemistry
Chemical mixing and mechanochemistry experts have experienced incredible advancements with the recent use of RAM technology.

Download our Chemical Mixing White Paper Below:

5 Little-Known RAM Examples of Chemical Mixing Success

Resonant Acoustic Mixing (RAM) has been successfully applied in various chemical mixing processes, offering advantages such as solvent-free reactions, enhanced mixing efficiency, and scalability. Here are some notable examples:

1. Solvent-Free Buchwald-Hartwig Amination

Researchers have utilized RAM for the Buchwald-Hartwig amination reaction without the need for bulk solvents. By systematically varying parameters like filling ratio, acceleration, and liquid additive amount, they achieved efficient and scalable reactions, highlighting RAM's potential in green chemistry applications. chemrxiv.org


2. Multigram-Scale Organic Synthesis

A study demonstrated the use of RAM for multigram-scale organic reactions, including the Knoevenagel condensation and Michael addition. The results showed that RAM could efficiently facilitate these reactions without the need for milling media, simplifying the process and reducing contamination risks. chemistry-europe.onlinelibrary.wiley.compubs.rsc.org+2nature.com+2onlinelibrary.wiley.com+2


3. Halogen-Bonded Cocrystal Formation

RAM has been employed to synthesize halogen-bonded cocrystals through neat and liquid-assisted mixing. This method offers a gentle mechanochemical approach, enabling the formation of cocrystals without the need for extensive solvent use or mechanical grinding. researchgate.net+7pubs.rsc.org+7sciencedirect.com+7


4. Synthesis of DNA and RNA Fragments

In the field of nucleic acid chemistry, RAM has been applied to synthesize short DNA and RNA fragments without bulk solvents. This approach significantly reduces solvent usage and allows for efficient coupling reactions, demonstrating RAM's applicability in sensitive biochemical processes. pubs.rsc.org


5. Photo-Mechanochemical Reactions

RAM has been explored as a platform for photo-mechanochemical applications, combining mechanical mixing with photochemical reactions. This integration enables sustainable and efficient synthesis pathways, expanding the scope of RAM in advanced material synthesis. nature.com


These examples underscore RAM's versatility and effectiveness in chemical mixing and synthesis, offering cleaner, faster, and more scalable alternatives to traditional methods. If you're interested in more detailed information or specific applications, feel free to ask!

Ready to find out more?

Drop us a line for a free demo or quote!

CHEMICAL MIXER
CASE STUDIES

“ResonantAcoustic® Mixing (RAM) enables mechanochemical organic synthesis that avoids milling or crushing media, as well as bulk solvents. The RAM methodology enables significant simplification and improvement of mechanochemical olefin metathesis, the first mechanochemical strategy for ene-yne metathesis, and permits the direct, 200-fold scaling-up of the mechanochemical synthesis of pharmaceutically active sulfonylureas, without any significant changes to reaction conditions or conversion. ” 

- Angewandte Chemie International Edition, 2022

“Our Testing with ResonantAcoustic® technology has demonstrated filler incorporation at phenomenal rates and with very little viscous heating. This technology could have a far broader impact on the Chemical Industry than anyone is imagining today”

- Senior Process engineering specialist – Global Chemical Company

“The use of resonant acoustic mixing as a simple, rapid and readily scalable methodology for synthesizing metal–organic frameworks of different levels of complexity, including two- and three-dimensional networks, has been demonstrated” 

–Chemical Science, 2020

THE UNIVERSAL BATCH
CHEMICAL MIXING SOLUTION

The ResonantAcoustic® Mixer (RAM) product line harnesses the power of resonance (low-frequency sound) to generate powerful and efficient chemical mixing of complex Solid-Solid, Solid-Liquid, Liquid-Gas, and Liquid-Liquid Blends.   RAM systems provide;

  • 10-100X faster mixing times
  • bladeless non-contact mixing
  • consistent homogenization
  • end cross contamination
  • repeatable every time
  • scalable
  • made in the USA
  • custom engineered systems
  • built to last
  • amazing cost savings
  • eco-friendly operation
  • unmatched safety

Videos on Mechanochemistry and Chemical Mixing

 

ResonantAcoustic® Mixing (RAM) Mixing Minute - Mechanochemistry

Dr. Tomislav Friščić - Leverhulme International Professor in Green and Sustainable Chemistry at the University of Birmingham in the UK explains the INCREDIBLE benefits of ResonantAcoustic® Mixing (RAM) in the field of Mechanochemistry over legacy technologies at Resodyn's Technical Interchange.

Client Testimonial - Hyaluronic Acid Crosslinking in as little as 1 minute with ResonantAcoustic Mixing!

ResonantAcoustic® Mixing (RAM) for Innovation in Cosmetics and Pharmaceuticals.

Successful application of ResonantAcoustic® Mixing (RAM) technology to Hyaluronic Acid (HA) crosslinking leads to significant technological advantages and at the same time allows crosslinked HA gels.

Polymer and Viscous Liquid Blending in 4 Seconds!

Many polymer based processing applications require additional ingredients for performance or coloration. To illustrate RAM’s ability to quickly and thoroughly mix ingredients of different characteristics, 2.5 grams of food coloring was blended with 235 grams of a polymer surrogate in 4 seconds! The final mixture shows the liquid fully dispersed within the polymer due to the unique and effective mixing action captured in the high speed footage.

Uniform Blending of Dissimilar Powders in 10 Seconds!

Dry ingredients can be difficult to thoroughly and consistently mix, particularly when the particles are of different sizes and characteristics. To illustrate effective and rapid mixing, 10 grams of fumed silica is blended with 100 grams of sand in 10 seconds! Completed specimens exhibit no airborne fumed silica, demonstrating uniform blending at an order of magnitude difference in particle size.

Published Articles on Mechanochemistry and Chemical Mixing

Mechanochemical Synthesis of Boroxine-linked Covalent Organic Frameworks

Materials Chemistry

https://doi.org/10.26434/chemrxiv-2024-d7znt

Enhancement of Co2 Adsorption Kinetics Onto Carbon by Low-Frequency High Amplitude Resonant Vibrations

Carbon Trends

https://doi.org/10.1016/j.cartre.2024.100361 

Solvent-free surface modification of milled carbon fiber using resonant acoustic mixing

Applied Surface Science

https://doi.org/10.1016/j.apsusc.2023.158865

Halogen-bonded cocrystals via resonant acoustic mixing

Mechanochemistry

https://doi.org/10.1039/d3mr00028a

Resonant acoustic mixing (RAM) for efficient mechanoredox catalysis without grinding or impact media

Chemical Communications

https://doi.org/10.1039/d2cc06013b

Milling Media-Free Suzuki Coupling by Direct Mechanocatalysis- From Mixer Mills to Resonant Acoustic Mixers

European Journal

https://doi.org/10.1002/chem.202301714

Direct mechanocatalysis by resonant acoustic mixing (RAM)

Chemical Science

https://doi.org/10.1039/d3sc01591b

The “η-sweet-spot” (ηmax) in liquid-assisted mechanochemistry: polymorph control and the role of a liquid additive as either a catalyst or an inhibitor in resonant acoustic mixing (RAM)

Faraday Discussions

https://doi.org/10.1039/d2fd00131d

Application of resonant acoustic mixing in the synthesis of vitamin C–nicotinamide variable stoichiometry cocrystals

Faraday Discussions

https://doi.org/10.1039/d2fd00124a

Tinkering with Mechanochemical Tools for Scale Up

Angewandte Chemie

https://doi.org/10.1002/ange.202300819

Metal‐Catalyzed Organic Reactions by Resonant Acoustic Mixing

Angewandte Chemie International Edition

https://doi.org/10.1002/anie.202115030

Resonant acoustic-mixing technology as a novel method for production of negative-temperature coefficient thermistors

Journal of Materials Science Materials in Electronics

https://doi.org/10.1007/s10854-022-08110-2

Time‐resolved in situ monitoring of mechanochemical reactions

Angewandte Chemie International Edition

https://doi.org/10.1002/anie.202117270

Application of mechanochemical activation in synthetic organic chemistry

Nontraditional Activation Methods in Green and Sustainable Applications

https://doi.org/10.1016/b978-0-12-819009-8.00001-3

Simple, scalable mechanosynthesis of metal–organic frameworks using liquid-assisted resonant acoustic mixing (LA-RAM)

Chemical Science

https://doi.org/10.1039/d0sc00333f

Mechanochemistry for organic chemists: An update

European Journal of Organic Chemistry

https://doi.org/10.1002/ejoc.201700961

Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing

Chemical Communications

High-throughput screening and scaleup of cocrystals using resonant acoustic mixing

International Journal of Pharmaceutics

Relevant Patents for Mechanochemistry and Chemical Mixing

Approved and pending applications for work involving the use of ResonantAcoustic® mixing technology.

Powder Blend Processability Improvements Through Minimal Amounts Of Synergistically Selected Surface Coating Agents

Highlighted Use: A LabRAM coated an API with Aerosil A200.

Composition, magnetic particle-containing film, and electronic component

Highlighted Use: RAM technology created a stable material with excellent magnetic anisotropy.

Method for production of composite magnetic powders by autonomous grinding

Highlighted Use: RAM combined ferromagnetic and ceramic particles.

Complexes Comprising Carbohydrate Polymers and Active Ingredients and Methods for Their Preparation

Highlighted Use: RAM technology combined carbohydrate polymers and biologically active compounds.

A method to produce and scale-up cocrystals and salts via resonant acoustic mixing

Highlighted Use: RAM technology can eliminate solvents and grinding material.

Learn More Relevant Details On Patent Pages and the Mechanochemistry Folio listed below.

CHEMICAL MIXING
PROCESSING PRODUCTS

LabRAM II

1,000 gram capacity for development

Up to 2.2 lb (1,000 gram) payload capacity full-featured, digitally controlled batch mixer for bench-scale development, mixing, and processing.

OmniRAM

5 kg capacity for pilot-scale production

Up to 2.2 lb (1,000 gram) payload capacity full-featured, digitally controlled batch mixer for bench-scale development, mixing, and processing.

RAM 5

36 kg capacity for pilot and production scale

80 lb (36 kg) payload capacity, digitally controlled, batch mixer with multiple processing capabilities and options for pilot production and processing.