Experience the Unmatched
Speed and Precision of ResonantAcoustic® Mixing (RAM)
Resodyn’s patented pharmaceutical mixers harness sound energy to deliver superior, uniform pharmaceutical mixes. Higher first-pass yields are achieved and out-of-specification material waste is reduced compared to standard mixers and blenders.
Client Testimonial
“Revolutionary... Fast...
Accurate... GAME CHANGING.”
Gus Bassani, PharmD
PCCA VP of R&D, PCD, Formulations
Why Resodyn?
Our industry-specific RAM products have revolutionized the pharmaceutical and biotechnology manufacturing process
RAM mixers provide exceptionally even mixing at breathtaking speed, which helps accelerate new product development, reducing time, complexity and cost.
Unmatched Performance
Our technology generates powerful, efficient mixing of complex blends of solids, liquids and gases. It is consistent regardless of scale and can be seamlessly applied to lab, bench, pilot and production applications.
RAM’s thorough, yet gentle, bladeless method ensures uniform, consistent API coating with or without solvents. Additionally, RAM does not damage APIs and eliminates contamination risks.
RAM excels at mixing:
- Amorphous solid dispersion
- Chembeads
- Collagen solutions
- Creams
- Dry powder coating
- High potency-low percentage API blends
- Nano-milling
- Small vial mixing
- Well plate mixing
- Pre-tablet powder blending
Other medical applications:
- Bone graft pastes and bone cement
- Dental composites
Scale From Bench to Industrial with Confidence
ResonantAcoustic® Mixing mixes virtually any combination of materials at scales ranging from bench development to industrial production.
Our single, powerful technology platform is trusted by the world’s top materials companies from international pharmaceutical and biotechnology manufacturers to global tech giants.
Whether you’re developing new materials in the laboratory or running full-scale industrial production, RAM systems are available in configurations to fit your application.
Out-Mix the Competition
- ResonantAcoustic Mixer
- V-Blender
- Paddle or Ribbon Mixers
- Helical Blender
Mixing MechanismDiffusion MixingConvective MixingDe-mixing
Uses up to 100 g to drive random particle motion to mix.Uses vessel movement at 60 Hz (~3,600 cycles per minute) to impart high energy chaotic motion.Random and chaotic motion of RAM prevents de-mixing.
Uses gravity (1g) as the restoring force to drive small scale random particle motion.Uses rotational movement at ~30 rpm to split and combine material systematically.The systematic motion of the v-blender can cause de-mixing.
Diffusion mixing is only a supplementary process for smaller particles and over longer mixing times.Use an impeller of some type to move particles from one location to another within the powder bed.
Some mixers have increased impeller speeds which will impart shear mixing to break down agglomerates.
If there is a difference in particle sizes, larger particles tend to settle at the bottom.
Particles with different densities can separate over time.
Overloading can reduce mixing efficiency and increase the risk of de-mixing.
Diffusion mixing may occur at the particle level, but its contribution is minimal to negligible.Helical blades create a 3-dimensional mixing pattern, lifting and folding the material to create bulk movement.Differences in particle sizes can lead to segregation.
Variations in material density can cause components to separate.
Overloading can reduce mixing efficiency and increase the risk of de-mixing.
Incorrect mixer speed can affect performance and contribute to de-mixing.
Case Study:
RAM goes beyond FDA guidelines
In a recent study, ResonantAcoustic® Mixing (RAM) was put to the test mixing a broad spectrum of APIs and excipients.
The results: RAM outperformed all conventional traditional pharmaceutical mixing technologies on the most important benchmarks.
- Superior speeds: RAM achieved thorough mixing of all APIs and excipients in just 2-4 minutes, typically 10-100 times faster than traditional methods.
- Beating benchmarks: All RAM mixes demonstrated RSD values well under the FDA’s required “readily mixed” threshold of 6% and also well below the 4% industry benchmark.
Client Testimonial: Hyaluronic Acid Crosslinking with RAM!
Client Testimonial
Experience the power of RAM firsthand with our expert team
Our sales professionals offer high-impact, on-site product demonstrations and personalized mixing tests using your materials — all at no cost to you. Discover the difference Resodyn can make for your operations today.
RAM pharmaceutical mixers
Our industry-specific ResonantAcoustic® Mixers are the pharmaceutical and biotechnology processing technology of choice. We have models to scale with your business, ensuring consistent efficiency from clinical trial to full-scale production.
PharmaRAM I
Capacity: Up to 0.7 lb (300 g)
Efficient batch mixer with simplified, rapid controls for pharmaceutical compounding and small sample processing. Ideal for repetitive and precursor processes.
- Easy-to-use controls
- Low, medium and high (40, 60, and 80 g) mixing acceleration settings
PharmaRAM II
Capacity: Up to 2.2 lb (1,000 g)
Delivers better results than traditional mixers through improved efficiency and enables new product opportunities at a payload capacity that bridges developmental scale with larger batch and continuous production.
- Touch screen interface
- Onboard operating system for real-time monitoring, recipe storage and data retention
- Scales easily from development to production without additional testing
- Mix at vacuum or pressure
- Temperature measurement/control are available with a jacketed vessel system
- 0-100g of powerful acceleration (100x the acceleration of gravity) at approximately 60 Hz (3600 RPM)
OmniRAM Pharma
Capacity: Up to 11 lb (5 kg)
Full-featured, digitally controlled batch mixer for larger-scale pharmaceutical development, clinical trials and pre- production processing.
RAM 5 Pharma
Capacity: Up to 80 lb (36 kg)
Delivers better results than traditional mixers through improved efficiency and enables new product opportunities at a payload capacity that bridges developmental scale with larger batch and continuous production.
RAM 55 Pharma
Capacity: Up to 924 lb (420 kg)
High-capacity batch mixer for large-scale pharmaceutical production, ensuring seamless scale-up from bench development.
Key features for all pilot and production scale models:
- 0-100g powerful acceleration (100x the acceleration of gravity) at approximately 60 Hz (3600 RPM)
- Consistent acceleration capability at the same amplitude, provides the continuity that makes scale-up a breeze.
- Configurable for continuous production
- Advanced and customizable mix vessel and enclosure designs are available to meet client requirements
Continuous Acoustic Mixer (CAM)
Capacity: Dependent upon model
Custom-built, high-throughput acoustic mixing systems for powders, pastes and liquids.
Configurable for:
- OmniRAM
- RAM 5
- RAM 55
- Customizable for specific applications
- Suitable for a wide range of materials
- 0-100g powerful acceleration (100x the acceleration of gravity) at approximately 60 Hz (3600 RPM)
- Consistent acceleration capability at the same amplitude, provides the continuity that makes scale-up a breeze.
