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THE PHARMACEUTICAL MIXING TECHNOLOGY OF
CHOICE FOR THOSE "IN THE KNOW"
Resodyn Acoustic Mixers, Inc. provides industry specific RAM products to the pharmaceutical and biotechnology manufacturing industries which provide for uniform mixing of disparate materials, excipients, liquids, and varying combinations under strict quality control.
The Batch to Batch reliability provided by the ResonantAcoustic® Pharmaceutical Mixing technology is unmatched. Integration of RAM products into development and manufacturing processes results in superior ingredient distribution, reduced pharmaceutical mixing time and a highly repeatable mixing process.
RAM processing is self-contained and can be aseptic, effectively eliminating cross-contamination concerns as well as cleaning.
RAM systems have illustrated acceleration of new product development. RAM technology is consistent regardless of scale and can be seamlessly applied to lab, bench, pilot, and production applications, including:
- Amorphous Solid Dispersion
- Bone Graft Pastes and Bone Cement
- Chembeads
- Collagen Solutions
- Creams
- Dental Composites
- Dry Powder Coating
- High Potency-Low Percentage API Blends
- Nano-milling
- Pre-Tablet Powder Blending
- Small Vial Mixing
- Well Plate Mixing

PHARMACEUTICAL MIXER
TESTIMONIALS
“…[We had] challenges with mixing a viscous (~10,000cp) solids-loaded cream
consisting of water, excipient, API, and a sticky acrylate adhesive. It used to take
multiple material addition steps and up to 8 hours with an overhead stirrer to
achieve desired uniformity. With a LabRAM we performed the mix in a little more
than 2min…”
- U.S. biopharmaceuticals company
“...having these LabRAM II units has changed our processes in a positive manner.
Every process involved with these units has become more stream-lined, and yield
better and more consistent results.”
- Global pharmaceutical company
“We use these LabRAMs day in and day out, 18-20 hours a day…we run the heck
out of them. We’re mixing several different powders in different quantities and no
liquids. These [LabRAM] mixers do the trick.”
- U.S.-based neutraceuticals company
THE UNIVERSAL PHARMACEUTICAL
MIXING SOLUTION OF CHOICE
The ResonantAcoustic® Mixer (RAM) product line harnesses the power of resonance (low-frequency sound) to generate powerful and efficient mixing of complex Solid-Solid, Solid-Liquid, Liquid-Gas, and Liquid-Liquid Blends. Benefits include;
- 10-100X faster mixing times
- bladeless non-contact mixing
- consistent homogenization
- erase cleaning & cross contamination
- repeatable
- scalable
- durable
- custom engineered systems
- reliable
- cost saving
- eco-friendly operation
- unmatched safety
Videos on Pharmaceutical Mixing
Client Testimonial - Catalent
See how Catalent Pharmaceuticals in the UK uses RAM to drive growth and boost profits. The Swindon, UK facility houses the Zydis® fast dissolving tablet development and manufacturing operation as well as a CMC pharmaceutical analytical lab services unit that offers ASAP stability.
ResonantAcoustic® Mixing is discussed between the 39 second mark and 59 second mark.
Client Testimonial - Abbvie
ChemBeads: chemistry coated in glass
What do tiny glass beads, a powder mixing machine and solid chemicals have in common?
Not much. Until a group of AbbVie chemists had an idea that could shorten the screening time for some compounds from weeks to days.
Long before there is a medicine, there is a compound. Or rather, thousands of compounds that must be tested in order to find the special few that could one day become a medicine. It’s a long and resource-heavy testing process to identify these “lead compounds” that could possibly be converted into a new medicine.
To test these compounds, scientists first have to make them. Unfortunately, finding the conditions necessary to make the desired compounds can often be a bottleneck, in part due to the limited amount of material available and a lack of technologies to screen diverse conditions efficiently and effectively. In other words, it adds a time consuming, resource-heavy step to what is already a painfully slow journey from scientific discovery to potential treatment.
After a few false starts, the team was inspired by a process where medicines are mixed with other inert materials to improve their solid characteristics. They found that glass beads can be coated with solid chemicals by combining them in a dry mixer. Solid chemicals are often very different from each other in terms of physical characteristics, but the chemical coated beads have very similar features, which makes a robot’s job much easier.
...our original RAM coating method is the most versatile for the broadest range of solids... - Impastato, A. C., Brown, J. T. C., Wang, Y., & Tu, N. P. (2023). Readily Accessible High-Throughput Experimentation: a general protocol for the preparation of ChemBeads and EnzyBeads. ACS Medicinal Chemistry Letters, 14(4), 514–520.
Watch Noah Tu, M.S., Senior Scientist, Discovery Chemistry and Technologies, AbbVie demonstrate the process:
Client Testimonial - Hyaluronic Acid Crosslinking in as little as 1 minute with ResonantAcoustic Mixing!
ResonantAcoustic® Mixing (RAM) for Innovation in Cosmetics and Pharmaceuticals.
Successful application of ResonantAcoustic® Mixing (RAM) technology to Hyaluronic Acid (HA) crosslinking leads to significant technological advantages and at the same time allows crosslinked HA gels.
Experience the Unmatched Speed and Precision of ResonantAcoustic® Mixing (RAM)
ResonantAcoustic® Mixing has transformed the pharmaceutical and biotechnology mixing landscape, setting a new standard of excellence. RAM enables the mixing of powders, liquids, slurries, or pastes at almost any scale, all without the risk of cross-contamination.
Client Testimonial - PCCA RAM Mixer Information and Demonstration
The PCCA RAM Mixer is demonstrated and explained at PCCA conference.
While this video is specific to compounding, the value propositions are broadly applicable to the pharmaceutical mixing industry:
- Uniformity
- Industry-leading Relative Standard Deviation (RSD) results
- Speed
- Repeatability
- Potency
- Elimination of Cross-Contamination risks
The 14 minute and 15 second version of this video embedded below is worth the watch! Even if short on time, this longer version of the video is informative and entertaining! It includes the side-by-side time comparisons for Weighing, Mixing, and Cleaning, which were trimmed in the shorter version for brevity.
Key highlights (timestamps provided to help fast forward or rewind to a favorite part):
- Speaker Gus Bassani, PharmD, PCCA VP of R&D, PCD, Formulations begins at 1:07
- Product is unveiled at 4:06
- First mix demonstration at 5:43 with a high speed camera to show the random motion
- Live powder mix at 6:05
- Start is pushed on the live mix at 7:05
- Though the machine was set for 1 minute, at 7:25, it is stopped because the mixing is complete after less than 20 seconds.
- Uniform results shown at 7:35
- Second live powder mix at 7:42
- Efficiency of the RAM demonstrated by comparing the capsule-making process of four different methods at 9:00
- Side-by-side video comparisons 9:24-10:48:
- RAM
- Blender
- Mortar and Pestle
- V-Blender
- Ready for Encapsulation results shown at 10:48 (weighing for each method was 1 minute, 20 seconds, so time for mixing is in parentheses):
- RAM took 4 minutes, 11 seconds
- Blender took 7 minutes, 1 second
- Mortar and Pestle took 9 minutes, 17 seconds
- V-Blender took 43 minutes and 13 seconds
- Cleaning demonstrated at 11:00-11:30:
- RAM took 1 second (includes instant replay)
- Blender took 5 minutes, 40 seconds
- Mortar and Pestle took 4 minutes, 31 seconds
- V-Blender took 5 minutes, 48 seconds
- Total time for each method displayed at 11:38 for Weighing, Mixing, and Cleaning:
- RAM took 4 minutes, 12 seconds
- Blender took 12 minutes, 41 seconds
- Mortar and Pestle took 13 minutes, 49 seconds
- V-Blender took 56 minutes, 2 seconds
- One more thing! Testing at 12:05 showing Content Uniformity with Averages and Relative Standard Deviation (RSD). No spoilers! Watch the video and be amazed!
Dissimilar Powder Mixing in 10 Seconds!
Dry ingredients can be difficult to thoroughly and consistently mix, particularly when the particles are of different sizes and characteristics. To illustrate effective and rapid mixing, 10 grams of fumed silica is blended with 100 grams of sand in 10 seconds! Completed specimens exhibit no airborne fumed silica, demonstrating uniform blending at an order of magnitude difference in particle size.
Milling and Nano Coating in 8 Seconds!
Coating larger particles with smaller ones is a common processing application, and milling is often a part of the same process. In this video, agglomerated carbon black particles are simultaneously milled to nano size particles that coat the plastic pellets completely in just a few seconds. The high speed video clearly illustrates the dispersion of carbon black particles, their de-agglomeration, and progressive and comprehensive coating of the plastic pellets.
Articles on Pharmaceutical Mixing
Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids
Pharmaceutics
“Coprecipitated ASD powders (overhead mixing and resonant acoustic mixing) demonstrated superior stabletability and flow properties when compared to
the spray drying powder. Careful choice of manufacturing process can be used to tune material properties of ASDs to make them more amenable for downstream operations like tableting.”
Tanaka, R., Osotprasit, S., Peerapattana, J., Ashizawa, K., Hattori, Y., & Otsuka, M. (2021). Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids. Pharmaceutics, 13(1), 56. https://doi.org/10.3390/pharmaceutics13010056
Applying Dry Powder Coatings
Pharmaceutical Technology
The LabRAM is a sophisticated bench-top mixer that exploits low frequency, high intensity, acoustic energy to rapidly fluidize and disperse as much as 500 g of a variety of materials.
Applying dry powder coatings. (2020b, November 15). PharmTech. https://www.pharmtech.com/view/applying-dry-powder-coatings
A novel method for preparing stabilized amorphous solid dispersion drug formulations using acoustic fusion
International Journal of Pharmaceutics
“A diverse set of drug and polymer combinations
have been effectively evaluated utilizing a newly developed method called acoustic fusion (which
employs a LabRAM) to form amorphous solid dispersions (ASD) on the mg-scale, indicating that this approach is a general procedure that can be applied for ASD drug formulations.”
Guo, Z., Boyce, C., Rhodes, T., Liu, L., Salituro, G. M., Lee, K., Bak, A., & Leung, D. H. (2020). A novel method for preparing stabilized amorphous solid dispersion drug formulations using acoustic fusion. International Journal of Pharmaceutics, 592, 120026. https://doi.org/10.1016/j.ijpharm.2020.120026
Influence of guest and host particle sizes on dry coating effectiveness: When not to use high mixing intensity
Powder Technology
“Examples from pharmaceutical applications include improving content uniformity of blends and powder flow...[using the] Resonant Acoustic Mixer (LabRAM) system...”
Zheng, K., Kunnath, K., Ling, Z., Chen, L., & Davé, R. N. (2020). Influence of guest and host particle sizes on dry coating effectiveness: When not to use high mixing intensity. Powder Technology, 366, 150–163. https://doi.org/10.1016/j.powtec.2020.02.059
Impact of Method of Preparation of Amorphous Solid Dispersions on Mechanical Properties: Comparison of Coprecipitation and Spray Drying
Journal of Pharmaceutical Sciences
“Resonant acoustic wet granulation (RAG) was devised in an effort to complete theophylline–citric acid (THPCIT) cocrystal formation during the granulation process, thereby reducing the number of operations.”
Hou, H. H., Rajesh, A., Pandya, K. M., Lubach, J. W., Muliadi, A., Yost, E., Jia, W., & Nagapudi, K. (2018). Impact of method of preparation of amorphous solid dispersions on mechanical properties: comparison of coprecipitation and spray drying. Journal of Pharmaceutical Sciences, 108(2), 870–879. https://doi.org/10.1016/j.xphs.2018.09.008
Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing
Chemical Communications
“The RAM technique...has been proposed as a method to perform mechanochemical processes under significantly more gentle conditions than those experienced during ball milling…”
Michalchuk, A. a. L., Hope, K. S., Kennedy, S. R., Blanco, M. V., Boldyreva, E. V., & Pulham, C. R. (2018b). Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing. Chemical Communications, 54(32), 4033–4036. https://doi.org/10.1039/c8cc02187b
Influence of Material Properties on the Effectiveness of Glidants Used to Improve the Flowability of Cohesive Pharmaceutical Powders
AAPS PharmSciTech
“... [a Turbula mixer] and a highly efficient and effective mixer (LabRAM vibratory mixer) were used to further understand the effect of material properties on glidant effectiveness.”
Sunkara, D., & Capece, M. (2018). Influence of material properties on the effectiveness of glidants used to improve the flowability of cohesive pharmaceutical powders. AAPS PharmSciTech, 19(4), 1920–1930. https://doi.org/10.1208/s12249-018-1006-3
Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS
Science
“The heterogeneous inorganic bases used in this study were made up as 0.5 M slurries in tert-amyl alcohol. When this mixture is irradiated on a PharmaRAM II Mixer at room temperature for 12 h at 18G in the presence of Norstone YTZ Grinding Media (0.5 mm), the resulting slurries do not significantly settle within 15 minutes on standing.”
Lin, S., Dikler, S., Blincoe, W. D., Ferguson, R. D., Sheridan, R. P., Peng, Z., Conway, D. V., Zawatzky, K., Wang, H., Cernak, T., Davies, I. W., DiRocco, D. A., Sheng, H., Welch, C. J., & Dreher, S. D. (2018). Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS. Science, 361(6402). https://doi.org/10.1126/science.aar6236
High-throughput screening and scale-up of cocrystals using resonant acoustic mixing
International Journal of Pharmaceutics
“RAM is...established as a scalable and environmentally friendly mechanochemical technique for the production of cocrystals.”
Nagapudi, K., Umanzor, E. Y., & Masui, C. (2017). High-throughput screening and scale-up of cocrystals using resonant acoustic mixing. International Journal of Pharmaceutics, 521(1–2), 337–345. https://doi.org/10.1016/j.ijpharm.2017.02.027
Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets
Advanced Powder Technology
“Studies…carried out for several blends having various values of particle size, cohesion and concentration of the active pharmaceutical ingredient [showed]
Resonant acoustic mixing is a good choice for blending low concentrations of cohesive APIs…”
Osorio, J. G., Sowrirajan, K., & Muzzio, F. J. (2016). Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets. Advanced Powder Technology, 27(4), 1141–1148. https://doi.org/10.1016/j.apt.2016.03.025
Verification of the mixing processes of the active pharmaceutical ingredient, excipient and lubricant in a pharmaceutical formulation using a resonant acoustic mixing technology
RSC Advances
“...RAM...efficiently contributes to powder flow and could produce an ideal mixing state with ease. The RAM method offers simple operation in comparison with ordinary method using a modified V-shape blender method, and it is expected to simplify pharmaceutical manufacturing facilities.”
Tanaka, R., Takahashi, N., Nakamura, Y., Hattori, Y., Ashizawa, K., & Otsuka, M. (2016). Verification of the mixing processes of the active pharmaceutical ingredient, excipient and lubricant in a pharmaceutical formulation using a resonant acoustic mixing technology. RSC Advances, 6(90), 87049–87057. https://doi.org/10.1039/c6ra16209f
Characterization of resonant acoustic mixing using near-infrared chemical imaging
Powder Technology
“Mixing in the RAM efficiently reduced the overall aggregate size of the cohesive API (semi-fine APAP, ~ 45 µm) used in a common blend of filler (microcrystalline cellulose, ~ 110 µm) and lubricant (magnesium stearate, ~ 10 µm).”
Osorio, J. G., Hernández, E., Romañach, R. J., & Muzzio, F. J. (2016). Characterization of resonant acoustic mixing using near-infrared chemical imaging. Powder Technology, 297, 349–356. https://doi.org/10.1016/j.powtec.2016.04.035
In-line and Real-time Monitoring of Resonant Acoustic Mixing by Near-infrared Spectroscopy Combined with Chemometric Technology for Process Analytical Technology Applications in Pharmaceutical Powder Blending Systems
Analytical Sciences
"This study examined the application of PAT with the combination of RAM, near-infrared spectroscopy, and chemometric technology as a set of PAT tools for introduction into actual pharmaceutical powder blending processes.”
Tanaka, R., Takahashi, N., Nakamura, Y., Hattori, Y., Ashizawa, K., & Otsuka, M. (2017). In-line and Real-time Monitoring of Resonant Acoustic Mixing by Near-infrared Spectroscopy Combined with Chemometric Technology for Process Analytical Technology Applications in Pharmaceutical Powder Blending Systems. Analytical Sciences, 33(1), 41–46. https://doi.org/10.2116/analsci.33.41
Evaluation of resonant acoustic mixing performance
Powder Technology
“The [LabRAM] resonant acoustic mixer reached minimum blend uniformity in as low as 30 seconds.”
Osorio, J. G., & Muzzio, F. J. (2015). Evaluation of resonant acoustic mixing performance. Powder Technology, 278, 46–56. https://doi.org/10.1016/j.powtec.2015.02.033
High-Throughput Tools for Optimizing Drug Nanosuspensions
Leung, D. H. (n.d.). High-Throughput tools for optimizing drug nanosuspensions. https://www.americanlaboratory.com/914-Application-Notes/171598-High-Throughput-Tools-for-Optimizing-Drug-Nanosuspensions/
Development and Scale-Up of Cocrystals Using Resonant Acoustic Mixing
Organic Process Research & Development
“…resonance acoustic mixing was applied to afford a practical and environmentally friendly approach to produce and scale up cocrystals.”
Ende, D. J. A., Anderson, S. R., & Salan, J. S. (2014). Development and Scale-Up of Cocrystals using resonant acoustic mixing. Organic Process Research & Development, 18(2), 331–341. https://doi.org/10.1021/op4003399
A new and improved method for the preparation of drug nanosuspension formulations using acoustic mixing technology
International Journal of Pharmaceutics
“…this [resonant acoustic mixing] approach [is] highly suitable for the rapid evaluation of potential drug candidates in the discovery and development space.”
Leung, D. H., Lamberto, D. J., Liu, L., Kwong, E., Nelson, T., Rhodes, T., & Bak, A. (2014b). A new and improved method for the preparation of drug nanosuspension formulations using acoustic mixing technology. International Journal of Pharmaceutics, 473(1–2), 10–19. https://doi.org/10.1016/j.ijpharm.2014.05.003
Relevant Pharmaceutical Mixing Patents
Approved and pending applications for work involving the use of ResonantAcoustic® mixing technology.
Process for making agglomerates using acoustic mixing technology
WO EP US JP AU CA AU2013345062B2 Sai Prasanth Chamarthy Merck Sharp & Dohme Corp.
Priority 2012-11-16 • Filed 2013-11-12 • Granted 2018-02-08 • Published 2018-02-08
Described herein is a process for preparing agglomerates comprising: (i) providing a dry powder mixture of one, two,
or three active pharmaceutical agent(s), and at least one excipient; and (ii) applying acoustic energy to said dry powder
mixture to form agglomerates.
Method to Produce and Scale-Up Cocrystals and Salts Via Resonant Acoustic …
EP US US20150080567A1 Jerry Salan Nalas Engineering Services Inc.
Priority 2013-09-04 • Filed 2014-08-28 • Published 2015-03-19
A method to produce and manufacture cocrystals and salts is disclosed wherein crystalline solids and other components
were combined in the desired proportions into a mixing chamber and mixed at high intensity to afford a cocrystalline
product. No grinding media were required. The mixing system …
Method and apparatus
WO EP US CN JP KR AU CA GB HK IL IN MX NZ RU SG MX2014011795A Matthew Green Vectura Ltd
Priority 2012-03-30 • Filed 2013-03-28 • Published 2015-01-12
A method is disclosed for making a pharmaceutical composition for pulmonary administration, the method comprising
a step in which an inhalable pharmaceutically active material is acoustically blended in a resonant acoustic blender. The
invention also relates to compositions for inhalation prepared …
Media milling process for the manufacture of active pharmaceutical ingredients …
WO EP US US20160317391A1 Balaji Bharatwaj Merck Sharp & Dohme Corp.
Priority 2013-12-17 • Filed 2014-12-12 • Published 2016-11-03
The invention disclosed herein is a novel media milling process performed in an atmosphere of propellants(s) utilizing
a resonant acoustic mixing (RAM) device. The process is utilized to reduce the particle size of API (optionally including
excipients) to a respirable size range while ensuring the …
Mechanical system that continuously processes a combination of materials
US US9808778B2 Lawrence C. Farrar Resodyn Corporation
Priority 2012-05-31 • Filed 2013-08-13 • Granted 2017-11-07 • Published 2017-11-07
The present application is directed towards systems and methods for continuously reacting a combination of materials
by use of an acoustic agitator and a continuous process vessel. The system can react, fluidize, mix, coat, dry, combine or
segregate materials. The continuous processing system can …
Method for producing dispersion and inkjet recording method
WO JP WO2018061989A1
Priority 2016-09-30 • Filed 2017-09-21 • Published 2018-04-05
Provided are: a method for producing a dispersion, comprising a step for obtaining a mixture by filling at least one type
of particles selected from inorganic particles and organic particles, a dispersing agent, and a dispersion medium in a
sealed container and mixing the substances filled in the …
Rapid allograft treatment systems and methods
WO EP US KR AU CA CL AU2016304809B2 Carolyn BARRETT RORICK Allosource
Priority 2015-08-07 • Filed 2016-08-08 • Granted 2020-09-24 • Published 2020-09-24
Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and
methods. The methods involve combining tissue with a processing solution in a processing vessel and applying resonant
acoustic energy thereto. In some instances, the tissue is …
Solventless mixing process for coating pharmaceutical ingredients
WO EP US CN JP AR BR DK ES HR HU PL PT RS SI WO2014062444A1 Rajesh N. Dave New Jersey Institute Of Technology
Priority 2012-10-15 • Filed 2013-10-09 • Published 2014-04-24
SOLVENTLESS MIXING PROCESS FOR COATING PHARMACEUTICAL INGREDIENTS BACKGROUND OF THE INVENTION 1.
Field of the Invention [0001] The present invention relates to coating active pharmaceutical ingredients for controlled
release or applications associated with controlled release such as taste masking.
Method for producing dispersion and method for producing pigment dispersion for …
WO US JP JP6742426B2
Priority 2016-09-30 • Filed 2017-09-15 • Granted 2020-08-19 • Published 2020-08-19
Step A of preparing a mixture containing an edible pigment, an edible dispersant, and water, A step B of applying a
hydrostatic pressure of 30 MPa or more to the mixture, A step C of performing a dispersion treatment on the mixture to
which the hydrostatic pressure is applied, A method for …
Systems and methods for producing homogenous pharmaceutical compositions
US US20170281530A1 Michael Bennett The Compounders Depot, Inc.
Priority 2016-04-05 • Filed 2017-04-05 • Published 2017-10-05
Embodiments of the present disclosure generally relate to systems and methods for mixing pharmaceutical compositions, agents and/or ingredients together. In one embodiment, a method can include a shell and a flexible pouch disposed within the shell. The flexible pouch can include at least one …
High Throughput Methods for Screening Chemical Reactions Using Reagent-Coated …
US US20190033185A1 Amanda Dombrowski Abbvie Inc.
Priority 2017-07-31 • Filed 2018-07-23 • Published 2019-01-31
Systems, methods, and compositions for high throughput screening of micro-scale chemical reactions are disclosed. In
particular, systems, methods, and compositions for handling small amounts of solid reagent are disclosed. For example,
mechanical mixing is employed to obtain reagent-coated bulking …
Rapid acoustic tissue processing methods, systems, and devices
US US20180280575A1 Ryan Delaney Allosource
Priority 2015-08-07 • Filed 2018-06-01 • Published 2018-10-04
Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and
methods. Also provided are ball mill processing devices and systems useful for processing materials such as tissue. The
methods involve combining tissue with or without a processing …
Methods of Producing Cellulose Nanocrystals
US US20190367704A1 Erik Dahl Uchicago Argonne, Llc
Priority 2018-06-05 • Filed 2018-06-05 • Published 2019-12-05
Presented herein for the first time are novel and highly efficient methods for producing CNCs. In exemplary embodiments, the method comprises mixing in a single reaction vessel a cellulose pulp, an acidic solution; and sodium chlorite,
wherein the sodium chlorite reacts to form a bleaching agent, …
Solventless particle coating via acoustic mixing
US US20210009767A1 Christopher LAVALLEE International Flavors & Fragrances Inc.
Priority 2019-07-11 • Filed 2020-07-10 • Published 2021-01-14
A method for coating solid granules containing a carbohydrate, gum Arabic, or protein by combining the solid granules
with at least one solid coating material, and applying acoustic energy to said combination is provided as are coated solid
granules prepared by the method.
Methods and Devices for Producing Cellular Suspensions from Tissue Samples
WO US US20210096046A1 Ronald J. Pettis Becton, Dickinson And Company
Priority 2016-03-10 • Filed 2020-12-15 • Published 2021-04-01
Aspects of the present disclosure include methods of producing a cellular suspension from a tissue sample by applying
resonant acoustic energy to a container comprising the tissue sample in a manner sufficient to produce a cellular suspension from the tissue sample. Resonant acoustic mixers and …
Pharmaceutical suspensions containing etoricoxib
WO WO2016036588A1 Michael HESLINGA Merck Sharp & Dohme Corp.
Priority 2014-09-03 • Filed 2015-08-28 • Published 2016-03-10
The present invention provides pharmaceutical suspensions containing etoricoxib particles having a median particle
diameter of 0.2 to 14 μm, and an aqueous injection vehicle. The present invention also provides methods for administering and preparing such compositions.
Method of converting a crystalline compound to an amorphous compound, method of …
WO EP US AU CA US20160235677A1 Robert A. Hoerr Nanocopoeia, Llc.
Priority 2014-11-25 • Filed 2015-11-25 • Published 2016-08-18
A method of converting a poorly water soluble crystalline compound to an amorphous compound and a method of
increasing the solubility of a poorly water soluble crystalline compound in biorelevant fluid at pH 6.5 is disclosed. The
method includes dissolving the compound and a polymer in a solvent …
Pharmaceutical Folio
White Papers
PHARMACEUTICAL
MIXING EQUIPMENT
PharmaRAM I
500 gram capacity for repetitive and small sample processing
Simple, rapid controls allow processing of small samples on the same technology platform as LabRAM II for repetitive and precursor processes, and vacuum capability.
PharmaRAM II
1 kg capacity delivers bench-scale development capabilities
Onboard operating system with recipe development and memory, real-time parameter monitoring, 100% processing data retention, multiple operator security levels. RAM technology scales easily without additional testing from development to pilot to production scales.
OmniRAM Pharma
5 kg capacity for larger than bench-scale development
OmniRAM Pharma has an 11 lb (5 kg) payload capacity, and is a full-featured, digitally controlled batch mixer for larger than bench scale development, clinical trials, pre and small-scale production and processing.
RAM 5 Pharma
36 kg capacity for pilot and production scale
Allows fast and efficient scale up from bench scale equipment with a full capabilities menu of temperature monitoring and control, mixing under vacuum, recipe development and retention, real-time parameter monitoring and recording, 100% processing data retention, multiple operator security levels, and product extraction options.