THE PHARMACEUTICAL PROCESSING
TECHNOLOGY OF CHOICE
Resodyn Acoustic Mixers, Inc. provides industry specific RAM products to the pharmaceutical and biotechnology manufacturing industries which provide for even mixing of disparate materials, excipients, liquids, and varying combinations under strict quality control.
The Batch to Batch reliability provided by the ResonantAcoustic® Mixer (RAM) technology is unmatched. Integration of RAM products into development and manufacturing processes results in superior ingredient distribution, reduced mixing time and a highly repeatable mixing process.
RAM processing is self-contained and can be aseptic, effectively eliminating cross-
RAM systems have illustrated acceleration of new product development. RAM technology is consistent regardless of scale and can be seamlessly applied to lab, bench, pilot, and production applications, including:
- Amorphous Solid Dispersion
- Bone Graft Pastes and Bone Cement
- Collagen Solutions
- Dental Composites
- Dry Powder Coating
- High Potency-Low Percentage API Blends
- Pre-Tablet Powder Blending
- Small Vial Mixing
- Well Plate Mixing
“…[We had] challenges with mixing a viscous (~10,000cp) solids-loaded cream
consisting of water, excipient, API, and a sticky acrylate adhesive. It used to take
multiple material addition steps and up to 8 hours with an overhead stirrer to
achieve desired uniformity. With a LabRAM we performed the mix in a little more
- U.S. biopharmaceuticals company
“...having these LabRAM II units has changed our processes in a positive manner.
Every process involved with these units has become more stream-lined, and yield
better and more consistent results.”
- Global pharmaceutical company
“We use these LabRAMs day in and day out, 18-20 hours a day…we run the heck
out of them. We’re mixing several different powders in different quantities and no
liquids. These [LabRAM] mixers do the trick.”
- U.S.-based neutraceuticals company
The ResonantAcoustic® Mixer (RAM) product line harnesses the power of resonance (low-frequency sound) to generate powerful and efficient mixing of complex Solid-Solid, Solid-Liquid, Liquid-Gas, and Liquid-Liquid Blends. Benefits include;
- 10-100X faster mixing times
- bladeless non-contact mixing
- consistent homogenization
- custom engineered systems
- cost saving
- eco-friendly operation
- unmatched safety
LEARN MORE ABOUT HOW
RAM CAN HELP YOU
PCCA RAM Mixer Information and Demonstration
The PCCA RAM Mixer is demonstrated and explained at PCCA conference.
Dissimilar Powder Mixing
Dry ingredients can be difficult to thoroughly and consistently mix, particularly when the particles are of different sizes and characteristics. To illustrate effective and rapid mixing, 10 grams of fumed silica is blended with 100 grams of sand. Completed specimens exhibit no airborne fumed silica, demonstrating uniform blending at an order of magnitude difference in particle size.
Milling and Nano Coating
Coating larger particles with smaller ones is a common processing application, and milling is often a part of the same process. In this video, agglomerated carbon black particles are simultaneously milled to nano size particles that coat the plastic pellets completely in just a few seconds. The high speed video clearly illustrates the dispersion of carbon black particles, their de-agglomeration, and progressive and comprehensive coating of the plastic pellets.
Learn Why RAM is the
Mixing Technology of Choice for Pharmaceutical Processing
Download this folio of testimonials along with links to technical papers/articles and relevant patents involving RAM and it's impact on the development of pharmaceutical processing.
500 gram capacity for repetitive and small sample processing
Simple, rapid controls allow processing of small samples on the same technology platform as LabRAM II for repetitive and precursor processes, and vacuum capability.
1 kg capacity delivers bench-scale development capabilities
Onboard operating system with recipe development and memory, real-time parameter monitoring, 100% processing data retention, multiple operator security levels. RAM technology scales easily without additional testing from development to pilot to production scales.
RAM 5 Pharma
36 kg capacity for pilot and production scale
Allows fast and efficient scale up from bench scale equipment with a full capabilities menu of temperature monitoring and control, mixing under vacuum, recipe development and retention, real-time parameter monitoring and recording, 100% processing data retention, multiple operator security levels, and product extraction options.