Our customers include:
Note: customer logos are registered trademarks for their respective organizations and do not constitute and endorsement.
Resonant Acoustic Mixing (RAM) has become the platform of choice for mechanochemists worldwide — and for good reason. RAM requires no grinding media, no bulk solvents, and no elevated temperatures, delivering precisely controlled mechanical energy uniformly throughout the entire reaction vessel. The result is faster, cleaner, and more scalable mechanochemical synthesis than any conventional method can achieve.
Dr. Tomislav Friščić, Leverhulme International Professor in Green and Sustainable Chemistry at the University of Birmingham and one of the most cited mechanochemists in the world, has called RAM a transformational technology for the field. His work — alongside collaborators at McGill University, Genentech, and institutions across the globe — has demonstrated RAM's ability to perform reactions previously accessible only by ball milling, while adding capabilities ball milling cannot match: precise energy control, seamless scale-up, and zero contamination from grinding media.
- No grinding media — eliminates contamination and particle damage
- Precise, tunable — control acceleration to tailor reactions
- Impossible reactions — chemistry that does not occur in conventional solvent environments
- Faster than ball milling — reactions completed in minutes rather than hours
- Scalable to high production — without reoptimization
- Continuous processing available — for high-throughput and industrial-scale synthesis
- Vacuum and inert atmosphere — process air- and moisture-sensitive materials without modification
Chemical Mixer Testimonials
“ResonantAcoustic® Mixing (RAM) enables mechanochemical organic synthesis that avoids milling or crushing media, as well as bulk solvents. The RAM methodology enables significant simplification and improvement of mechanochemical olefin metathesis, the first mechanochemical strategy for ene-yne metathesis, and permits the direct, 200-fold scaling-up of the mechanochemical synthesis of pharmaceutically active sulfonylureas, without any significant changes to reaction conditions or conversion. ”
- Angewandte Chemie International Edition, 2022
“Our Testing with ResonantAcoustic® technology has demonstrated filler incorporation at phenomenal rates and with very little viscous heating. This technology could have a far broader impact on the Chemical Industry than anyone is imagining today”
- Senior Process engineering specialist – Global Chemical Company
“The use of resonant acoustic mixing as a simple, rapid and readily scalable methodology for synthesizing metal–organic frameworks of different levels of complexity, including two- and three-dimensional networks, has been demonstrated”
–Chemical Science, 2020
500+ Independent Research Articles Prove RAM is Superior
Chemistry Research Featuring ResonantAcoustic® Mixers
Chemical Mixing Equipment Videos
RESONANT ACOUSTIC APPLICATIONS IN MECHANOCHEMISTRY
RAM is the mechanochemistry mixer capable of performing the full spectrum of solvent-free and solvent-minimized chemical synthesis. Here are the most documented applications where RAM has demonstrated clear advantages over ball milling and conventional solution chemistry:
Organic Synthesis
Cocrystallization
Materials Synthesis
Milling & Activation
- Metal-catalyzed C–N cross-coupling (nickel-catalyzed amination)
- Copper-catalyzed sulfonamide-carbodiimide coupling
- Copper-catalyzed alkyne-azide click chemistry (CuAAC)
- Ruthenium-catalyzed ring-closing metathesis
- Ene-yne metathesis
- High-throughput experimentation (HTE) screening
- Pharmaceutical cocrystals and salt forms
- Halogen-bonded cocrystalline architectures
- Polymorph control via liquid-assisted RAM (LA-RAM)
- Scale-up cocrystallization from lab to multi-ton production
- Stoichiomorphic cocrystals exclusive to RAM
- Metal-organic framework (MOF) synthesis (Zn, Co, Cu systems)
- ZIF-L and novel MOF frameworks inaccessible by other methods
- Coordination polymers and mixed-ligand systems
- Energetic cocrystals (CL-20:HMX)
- Media-free particle size reduction
- Mechanochemical activation of reaction precursors
- Liquid-assisted grinding (LAG) without grinding media
- Simultaneous milling and reaction in a single vessel
RAM Compliance in Mechanochemistry
RAM mechanochemistry mixers are designed for the full range of synthetic chemistry environments, including reactive, air-sensitive, and hazardous material processing. Discuss your specific application requirements with a sales engineer.
RAM CASE STUDIES IN CHEMICAL APPLICATIONS
How RAM Has Transformed Operations in Chemical Processing
VALIDATING RAM FOR CHEMICAL MIXING AND PROCESSING
Switching your chemical processing technology is a significant decision. RAM is available for evaluation and validation through a low-risk, step-by-step process designed to build your confidence before you commit.
- Demonstration
A sales engineer will arrange an online demonstration via conference call to show you a lab scale version or
RAM so you can see for yourself how it works. In some locations, we can offer in-person visits. - Free material testing
We can arrange a free mix, coating, milling, or reaction test with your material or a suitable surrogate. You
send us the material, we process it, document it, and send it back to you for validation. Material SDS required,
no hazardous materials accepted. - Rental program
We offer the LabRAM I for a monthly rental, with the first month’s rent applying to the cost of a purchase. Try
RAM out in your lab and run as many tests as you would like. - Quotation
Once you have had time to evaluate RAM through either a demonstration, mix test, or rental, we will provide a
quote that matches your application needs, however simple or complex they may be. - Performance Testing
After purchase, we can also perform validation and testing (FAT, SAT, etc) of your new machine per your
requirements, including compliance, performance, quality, and safety tests prior to or post installation.
Patents Featuring RAM Technology
Many of our customers discover that RAM mixing, milling, coating, and chemical reaction technology is so powerful, they apply for US and International patents to protect their process design and newfound competitive edge.
Key examples include: