THE PHARMACEUTICAL PROCESSING
TECHNOLOGY OF CHOICE
Resodyn Acoustic Mixers, Inc. provides industry specific RAM products to the pharmaceutical and biotechnology manufacturing industries which provide for even mixing of disparate materials, excipients, liquids, and varying combinations under strict quality control.
The Batch to Batch reliability provided by the ResonantAcoustic® Mixer (RAM) technology is unmatched. Integration of RAM products into development and manufacturing processes results in superior ingredient distribution, reduced mixing time and a highly repeatable mixing process.
RAM processing is self-contained and can be aseptic, effectively eliminating cross-
contamination concerns.
RAM systems have illustrated acceleration of new product development. RAM technology is consistent regardless of scale and can be seamlessly applied to lab, bench, pilot, and production applications, including:
- Amorphous Solid Dispersion
- Bone Graft Pastes and Bone Cement
- Chembeads
- Collagen Solutions
- Creams
- Dental Composites
- Dry Powder Coating
- High Potency-Low Percentage API Blends
- Nano-milling
- Pre-Tablet Powder Blending
- Small Vial Mixing
- Well Plate Mixing
LEARN MORE ABOUT HOW
RAM CAN HELP YOU
PCCA RAM Mixer Information and Demonstration
The PCCA RAM Mixer is demonstrated and explained at PCCA conference.
NOTE: This version of the video is the 3 minute and 36 second version.
The 14 minute and 15 second version of this video embedded below is worth the watch! Even if short on time, this longer version of the video is informative and entertaining! It includes the side-by-side time comparisons for Weighing, Mixing, and Cleaning, which were trimmed in the shorter version for brevity.
Key highlights (timestamps provided to help fast forward or rewind to a favorite part):
- Speaker Gus Bassani, PharmD, PCCA VP of R&D, PCD, Formulations begins at 1:07
- Product is unveiled at 4:06
- First mix demonstration at 5:43 with a high speed camera to show the random motion
- Live powder mix at 6:05
- Start is pushed on the live mix at 7:05
- Though the machine was set for 1 minute, at 7:25, it is stopped because the mixing is complete after less than 20 seconds.
- Uniform results shown at 7:35
- Second live powder mix at 7:42
- Efficiency of the RAM demonstrated by comparing the capsule-making process of four different methods at 9:00
- Side-by-side video comparisons 9:24-10:48:
- PCCA RAM
- Blender
- Mortar and Pestle
- V-Blender
- Ready for Encapsulation results shown at 10:48:
- PCCA RAM took 4 minutes, 11 seconds
- Blender took 7 minutes, 1 second
- Mortar and Pestle took 9 minutes, 17 seconds
- V-Blender took 43 minutes and 13 seconds
- Cleaning demonstrated at 11:00-11:30:
- PCCA RAM took 1 second (includes instant replay)
- Blender took 5 minutes, 40 seconds
- Mortar and Pestle took 4 minutes, 31 seconds
- V-Blender took 5 minutes, 48 seconds
- Total time for each method displayed at 11:38 for Weighing, Mixing, and Cleaning:
- PCCA RAM took 4 minutes, 12 seconds
- Blender took 12 minutes, 41 seconds
- Mortar and Pestle took 13 minutes, 49 seconds
- V-Blender took 56 minutes, 2 seconds
- One more thing! Testing at 12:05 showing Content Uniformity with Averages and Relative Standard Deviation (RSD). No spoilers! Watch the video and be amazed!
Dissimilar Powder Mixing
Dry ingredients can be difficult to thoroughly and consistently mix, particularly when the particles are of different sizes and characteristics. To illustrate effective and rapid mixing, 10 grams of fumed silica is blended with 100 grams of sand. Completed specimens exhibit no airborne fumed silica, demonstrating uniform blending at an order of magnitude difference in particle size.
Milling and Nano Coating
Coating larger particles with smaller ones is a common processing application, and milling is often a part of the same process. In this video, agglomerated carbon black particles are simultaneously milled to nano size particles that coat the plastic pellets completely in just a few seconds. The high speed video clearly illustrates the dispersion of carbon black particles, their de-agglomeration, and progressive and comprehensive coating of the plastic pellets.
Learn Why RAM is the
Mixing Technology of Choice for Pharmaceutical Processing
Download this folio of testimonials along with links to technical papers/articles and relevant patents involving RAM and it's impact on the development of pharmaceutical processing.
PHARMACEUTICAL
PRODUCTS
PharmaRAM I
500 gram capacity for repetitive and small sample processing
Simple, rapid controls allow processing of small samples on the same technology platform as LabRAM II for repetitive and precursor processes, and vacuum capability.
PharmaRAM II
1 kg capacity delivers bench-scale development capabilities
Onboard operating system with recipe development and memory, real-time parameter monitoring, 100% processing data retention, multiple operator security levels. RAM technology scales easily without additional testing from development to pilot to production scales.
OmniRAM Pharma
5 kg capacity for larger than bench-scale development
OmniRAM Pharma has an 11 lb (5 kg) payload capacity, and is a full-featured, digitally controlled batch mixer for larger than bench scale development, clinical trials, pre and small-scale production and processing.
RAM 5 Pharma
36 kg capacity for pilot and production scale
Allows fast and efficient scale up from bench scale equipment with a full capabilities menu of temperature monitoring and control, mixing under vacuum, recipe development and retention, real-time parameter monitoring and recording, 100% processing data retention, multiple operator security levels, and product extraction options.
