Relevant Patents for Mechanochemistry and Chemical Mixing
Approved and pending applications for work involving the use of ResonantAcoustic® mixing technology.
Powder Blend Processability Improvements Through Minimal Amounts Of Synergistically Selected Surface Coating Agents
US US20240024241A1 Rajesh N. Dave, Sangah Kim & Zhixing Lin New Jersey Institute Of Technology
Priority 2022-07-12 • Filed 2023-07-12 • Published 2024-01-25
High(greater than 30%) and/or low(less than 10%) loaded multiple API powdered/nanoparticle were tabulated with increased flowability and physical properties. Properties include blend flowability and uniformity, bulk packing density, compactability, tensile strength, and dissolution. Blending is done through solventless dry mechanical coating of at least one minority API component defined as the API component with the least weight per volume surface coated with nano-sized powders in lesser amounts by wt % of the blend, and preferably less than 10% dry coated of the minority API. An excipient may be dry coated in the lesser amount wherein the excipient is a minority component. Both minority excipient and minority API may be dry coated. Using dry coating instead of dry granulation and/or wet granulation techniques in producing tablets saves manufacturing steps, costs, and produces higher quality tablets with surprisingly higher properties than expected for low flowability solid powdered ingredients.
Highlighted Use: A LabRAM coated an API with Aerosil A200.
Composition, magnetic particle-containing film, and electronic component
WO EP US JP TW US20230238164A1 Tatsuo Ishikawa Fujifilm Corporation
Priority 2020-09-18 • Filed 2023-03-15 • Published 2023-07-27
An object of the present invention is to provide a composition that can form a magnetic particle-containing film having excellent magnetic permeability and excellent acid resistance, and has excellent sedimentation stability. Another object of the present invention is to provide a magnetic particle-containing film that relates to the composition, and an electronic component that includes the magnetic particle-containing film. The composition according to an embodiment of the present invention contains magnetic particles that contain 70% to 90% by mass of Fe atoms and have a crystal structure of Fe, an average particle diameter of 2 to 30 μm, and an aspect ratio less than 8, and a rheology control agent.
Highlighted Use: RAM technology created a stable material with excellent magnetic anisotropy.
Method for production of composite magnetic powders by autonomous grinding
SK SK132021A3, Bureš Radovan, Fáberová Mária
Priority 2021-2-25 • Filed 2021-2-25 • Published 2022-9-14
Ferromagnetism in the form of powdered magnetically soft metal or alloy is placed together with electro-insulating ceramic powder in a cylindrical container. The ratio of the height to the diameter of the container is 2:1. The container is filled with powder to a maximum of 1/3 of the volume. The powder mixture is autonomously ground by the action of resonant acoustic energy for 15 minutes to 360 hours. The particles of the powder mixture are given a gravitational acceleration of at least 20 g. Ferromagnetic particles are at least one order of magnitude larger than ceramic particles. Particles of the powder mixture are precipitated, ceramic particles are fragmented into smaller particles. Ferromagnetic particles act as a grinding medium. Fragmented ceramic particles are attached to the surface of ferromagnetic particles, the size of which does not change significantly during autonomous grinding. The powder composite material is further processed by pressing and sintering into magnetically soft components.
Highlighted Use: RAM combined ferromagnetic and ceramic particles.
Complexes Comprising Carbohydrate Polymers and Active Ingredients and Methods for Their Preparation
WO, EP, AU, JP, CA, US, JP2023510089A Felix Polyak, Dmitry Budovich
Priority 2019-12-13 • Filed 2020-12-11 • Published 2023-3-13
Disclosed herein are molecular complexes and compositions containing them. More specifically, carbohydrate polymers such as hyaluronic acid and its salts are bioactive selected from natural products and nutrients (amino acids, amino esters, hydroxy acids, hydroxy esters, vitamins, cannabinoids, etc.) and active pharmaceutical
ingredients. Complexes with compounds to form stable molecular complexes. Complexation can be conveniently achieved using resonant acoustic mixing methods.
Highlighted Use: RAM technology combined carbohydrate polymers and biologically active compounds.
A method to produce and scale-up cocrystals and salts via resonant acoustic mixing
US, EP EP2845852A1 Jerry Salan, Stephen R. Anderson, and David J. Am Ende, Nalas Engineering Services Inc.
Priority 2013-9-4 • Filed 2014-9-4 • Published 2015-3-11
A method to produce and manufacture cocrystals and salts is disclosed wherein crystalline solids and other components were combined in the desired proportions into a mixing chamber and mixed at high intensity to afford a cocrystalline product. No grinding media were required. The mixing system consists of a resonant acoustic vibratory system capable of supplying a large amount of energy to the mixture and is tunable to a desired resonance frequency and amplitude. The use of resonant acoustic mixing to assist cocrystallization is novel. This discovery enables the manufacture of cocrystals and salt forms, simplifying their manufacture and scale-up, and avoiding the use of grinding methods or grinding media. The present invention affords the manufacture of cocrystals and salts on kilogram to multi-ton scale and is adaptable to continuous manufacturing through the use of resonant mixing methods.
Highlighted Use: RAM technology can eliminate solvents and grinding material.
