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Gamechanging Chemical Mixer for
Advanced Synthesis and Processing

Chemical Mixing, Polymer Processing, Synthesis, and Reaction with ResonantAcoustic® Technology

Our customers include:

BASF logo
DOW logo
Sabic logo
Henkel logo
Johnson Matthey logo
Exxon Mobil logo

Note: customer logos are registered trademarks for their respective organizations and do not constitute and endorsement.

Resonant Acoustic Mixing (RAM) is transforming chemical processing across a wide range of applications — from polymer synthesis and surface modification to catalyst preparation and reactive chemistry. Scientists and engineers at global chemical companies, national laboratories, and universities have discovered that bladeless, closed-vessel mixing delivers uniformity, speed, and process control that conventional mixers simply cannot match. Here's why RAM is the chemical mixer redefining what's possible:

  • High speed and better uniformity — orders of magnitude faster
  • Gentle, low-shear — no blades, no impellers, no mechanical damage
  • Closed vessel operation — eliminates solvent evaporation, contamination
  • Solvent-free processing — dry chemical reactions, green chemistry
  • Consistent results at any scale — seamless scale-up
  • Multi-functional platform — mixing, reaction, coating, surface modification
  • Vacuum and temp control — process under controlled conditions
RAM5 mixer for production scale chemical synthesis

Chemical Mixer Testimonials

“ResonantAcoustic® Mixing (RAM) enables mechanochemical organic synthesis that avoids milling or crushing media, as well as bulk solvents. The RAM methodology enables significant simplification and improvement of mechanochemical olefin metathesis, the first mechanochemical strategy for ene-yne metathesis, and permits the direct, 200-fold scaling-up of the mechanochemical synthesis of pharmaceutically active sulfonylureas, without any significant changes to reaction conditions or conversion. ” 

- Angewandte Chemie International Edition, 2022

“Our Testing with ResonantAcoustic® technology has demonstrated filler incorporation at phenomenal rates and with very little viscous heating. This technology could have a far broader impact on the Chemical Industry than anyone is imagining today”

- Senior Process engineering specialist – Global Chemical Company

“The use of resonant acoustic mixing as a simple, rapid and readily scalable methodology for synthesizing metal–organic frameworks of different levels of complexity, including two- and three-dimensional networks, has been demonstrated” 

–Chemical Science, 2020

Resonant Acoustic Applications in the Chemical Industry

RAM delivers far more than mixing. ResonantAcoustic® technology is a versatile chemical processing platform used across synthesis, formulation, surface treatment, and reactive processing. Here are the most documented applications where RAM outperforms conventional methods:

Mixing Applications

Synthesis & Reaction Applications

Coating & Surface Modification Applications

Milling Applications

  • High-viscosity polymer blending
  • Highly loaded solid-liquid dispersions (up to 85% solids)
  • Multi-component resin formulation
  • Emulsification and phase inversion
  • Powder-liquid incorporation
  • Ring-opening polymerization (ROP)
  • Hyaluronic acid crosslinking
  • Polyester resin emulsification
  • Nanoparticle synthesis (Ag/N-doped carbon catalysts)
  • CO₂ adsorption enhancement on carbon adsorbents
  • Solvent-free carbon fiber surface modification (diazonium chemistry)
  • Nano-composite preparation
  • Particle surface coating and encapsulation
  • Catalyst support preparation
  • Particle size reduction without grinding media
  • Deagglomeration of nanomaterials
  • Simultaneous milling and coating in a single vessel

RAM Compliance in the Chemical Industry

RAM chemical mixers are designed for demanding processing environments, including hazardous, reactive, and solvent-bearing chemistries. Discuss your facility's specific compliance and safety requirements with a sales engineer.

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Continuous Process icon RAM
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VALIDATING RAM FOR CHEMICAL MIXING AND PROCESSING

Switching your chemical processing technology is a significant decision. RAM is available for evaluation and validation through a low-risk, step-by-step process designed to build your confidence before you commit.

  1. Demonstration
    A sales engineer will arrange an online demonstration via conference call to show you a lab scale version or
    RAM so you can see for yourself how it works. In some locations, we can offer in-person visits.
  2. Free material testing
    We can arrange a free mix, coating, milling, or reaction test with your material or a suitable surrogate. You
    send us the material, we process it, document it, and send it back to you for validation. Material SDS required,
    no hazardous materials accepted.
  3. Rental program
    We offer the LabRAM I for a monthly rental, with the first month’s rent applying to the cost of a purchase. Try
    RAM out in your lab and run as many tests as you would like.
  4. Quotation
    Once you have had time to evaluate RAM through either a demonstration, mix test, or rental, we will provide a
    quote that matches your application needs, however simple or complex they may be.
  5. Performance Testing
    After purchase, we can also perform validation and testing (FAT, SAT, etc) of your new machine per your
    requirements, including compliance, performance, quality, and safety tests prior to or post installation.
RAM 5 in Pharmaceutical Production
Customer performs Factory Acceptance Test (FAT) at Resodyn prior to shipping new RAM5 automated system

Patents Featuring RAM Technology

Seal of the United States Patent and Trademark Office

Many of our customers discover that RAM mixing, milling, coating, and chemical reaction technology is so powerful, they apply for US and International patents to protect their process design and newfound competitive edge.

Key examples include:

Research Featuring RAM Technology

Mechanochemical Synthesis of Boroxine-linked Covalent Organic Frameworks

Enhancement of Co2 Adsorption Kinetics Onto Carbon by Low-Frequency High Amplitude Resonant Vibrations

Solvent-free surface modification of milled carbon fiber using resonant acoustic mixing

Halogen-bonded cocrystals via resonant acoustic mixing

Resonant acoustic mixing (RAM) for efficient mechanoredox catalysis without grinding or impact media

Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing

Milling Media-Free Suzuki Coupling by Direct Mechanocatalysis- From Mixer Mills to Resonant Acoustic Mixers

Direct mechanocatalysis by resonant acoustic mixing (RAM)

The “η-sweet-spot” (ηmax) in liquid-assisted mechanochemistry: polymorph control and the role of a liquid additive as either a catalyst or an inhibitor in resonant acoustic mixing (RAM)

Application of resonant acoustic mixing in the synthesis of vitamin C–nicotinamide variable stoichiometry cocrystals

Tinkering with Mechanochemical Tools for Scale Up

Metal‐Catalyzed Organic Reactions by Resonant Acoustic Mixing

Resonant acoustic-mixing technology as a novel method for production of negative-temperature coefficient thermistors

Time‐resolved in situ monitoring of mechanochemical reactions

Application of mechanochemical activation in synthetic organic chemistry

Simple, scalable mechanosynthesis of metal–organic frameworks using liquid-assisted resonant acoustic mixing (LA-RAM)

Mechanochemistry for organic chemists: An update

High-throughput screening and scaleup of cocrystals using resonant acoustic mixing

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